Sodium alginate(sodium alginate, referred to as AGS), is extracted from kelp or seaweed salt of a polysaccharide, the molecular weight of 7 to 15 million. AGS clinical application has the potential to develop in depth, which are summarized as summarized below.
1 for the preparation of controlled-release formulations
AGS is a function of materials with controlled release, oral drug to add in the AGS, as viscosity increases, the extended release of drugs, can slow down the absorption and prolong the efficacy and reduce adverse reactions. AGS study found that the peripheral with aminophylline tablets, calcium gluconate tablets, a slow dissolution rate and release of S-shaped curve, indicating that the AGS on the control of drug release can play the role. AGS and calcium in acid conditions, can form calcium alginate gel can maintain a good type and good film strength and flexibility, to release the drug according to design requirements. Abroad, sustained-release tablets of isosorbide dinitrate is to AGS as a substrate made of domestic to AGS as a substrate film made of a long-acting isosorbide dinitrate. In antibiotics, insulin, hormone drug solution added to AGS, may also produce long-lasting effect. AGS obtained with blank alginate gel pellets in the solution of doxorubicin uptake of doxorubicin can take the initiative, and finally made adriamycin alginate gel pellets, which doxorubicin release rate can be different media control. AGS has a bio-adhesive, non-toxic, has good biocompatibility, not absorbed, easy to adhere to the moist tissue, mucosal drug delivery systems used for the adhesion of materials. Was made with the AGS as a substrate for nitric sigh membrane, placed in periodontal pockets treatment of periodontitis, achieved satisfactory results, and avoid long-term systemic adverse drug reactions.
2 material for wound healing
Wound repair materials to help promote wound healing is a medical biomaterials, tissue compatibility of these materials, plant or cover the wound and the body's adverse reaction does not occur, and can treat or replace body tissue in the defect and promote their healing. AGS is a kind of natural plant materials wound healing, with its production of gel diaphragm or sponge material can be used to protect the wound and treatment of burn and scald. AGS trauma care can be made with glycerin gel, dry skin membrane to become non-toxic soft gel or membrane containing drugs.Animal experiments show that it has to prevent bacterial infection of wounds and treatment of the role of film and easy to use water to wash away. Application AGS skin healing time of skin grafts, healing quality, and patient comfort are better than pigskin films. With the AGS as part of the inferior turbinate resection in patients with dressing material, dressing better than paraffin wax, remove the bandage can be particularly more pronounced reduction in bleeding. Sodium alginate with calcium (Ca2 +-GS) fibers can be successful in the treatment of toxic epidermal necrosis.
3 Treatment of reflux esophagitis
AGS treat oral postprandial gastroesophageal reflux (GER). Some children with AGS treatment of reflux esophagitis, GER can occur less often, shorter duration, esophageal pH, recovery speed, and can significantly reduce the incidence of vomiting. AGS as the main ingredient in chewing cover stomach plain film, is a domestic gastroesophageal acid reflux inhibitors, after swallowing after chewing, and saliva, gastric acid, to produce a floating viscous gel to form a full block back to physical barrier to protect the inflamed mucous membranes, promote healing. AGS in an oral treatment of reflux esophagitis controlled study, AGS is more effective than cisapride (cisapride).
4 to restore blood volume
701 made with the AGS injection, injection of Sodium alginate, sodium alginate oligosaccharides injection, said foreign Alginon, Glyco-Algin and so on. With increased blood volume, maintain blood pressure, can maintain a stable circulation before and after surgery for hemorrhagic shock, burns and shock, and acute diarrhea, dehydration, high fever due to systemic treatment, as well as the group generated by excluding burns rubber toxoid role.
5 Other
Documents extracted from wheat bran dietary fiber mixture of crushed and AGS, by adding 8% AGS as a thickening agent, plus 0.2% glucose sweet mix, and the other with 2% AGS for adhesives made from water soluble dietary fiber granules (DFG), the animal experiments and clinical observation. Results show that, DFG can significantly reduce high blood cholesterol in rats blood cholesterol (TC), triglycerides and low-density lipoprotein cholesterol (LDL-C), and the increase of these three indicators have a preventive role in normal rats glucose did not change, a significant increase in bowel movements; DFG can significantly reduce high blood cholesterol in patients with TC and LDL-C, significantly reduced Ⅰ, Ⅱ diabetes, fasting blood glucose, treatment of habitual constipation with efficiency of 100%. That long-term intake of 5% AGS will not only reduce blood fat rats, but can reduce liver fat, decreased liver weight / body weight ratio (P> 0.05), suggesting that the high-fat rats, the lower liver The role of lipid lowering body fat than the more significant. The prevention of high cholesterol and fatty liver, and can decrease platelet aggregation, useful for the prevention of thrombotic diseases, its better than carrageenan.
Studies, also, AGS can significantly promote the mouse peritoneal macrophage phagocytosis, and enhance humoral immunity and promote lymphocyte transformation of rat red blood cell agglutination significant role in promoting tumor S1809 has a certain extent, able to confront the cyclophosphamide-induced leukopenia. Can inhibit the body's absorption of lead, cadmium, strontium and other harmful non-factor. AGS with calcium, iron ions form a gel precipitation, the characteristics of improving water quality, cleaning up the environment has some economic value.
6 AGS adverse reactions
AGS mice by intraperitoneal injection of LD50 of (1 013 ± 308) mg · kg-1. 5 volunteers AGS results show that a large number of oral daily 175mg · kg0-1. 7d clothes, and then followed by daily 200mg · kg-1 even for 16d, in addition to the stool dry weight, wet weight and water content are increased, the clinical symptoms, and hematology, serology, enzymology, urine, feces and other tests were no any adverse reactions.
1 for the preparation of controlled-release formulations
AGS is a function of materials with controlled release, oral drug to add in the AGS, as viscosity increases, the extended release of drugs, can slow down the absorption and prolong the efficacy and reduce adverse reactions. AGS study found that the peripheral with aminophylline tablets, calcium gluconate tablets, a slow dissolution rate and release of S-shaped curve, indicating that the AGS on the control of drug release can play the role. AGS and calcium in acid conditions, can form calcium alginate gel can maintain a good type and good film strength and flexibility, to release the drug according to design requirements. Abroad, sustained-release tablets of isosorbide dinitrate is to AGS as a substrate made of domestic to AGS as a substrate film made of a long-acting isosorbide dinitrate. In antibiotics, insulin, hormone drug solution added to AGS, may also produce long-lasting effect. AGS obtained with blank alginate gel pellets in the solution of doxorubicin uptake of doxorubicin can take the initiative, and finally made adriamycin alginate gel pellets, which doxorubicin release rate can be different media control. AGS has a bio-adhesive, non-toxic, has good biocompatibility, not absorbed, easy to adhere to the moist tissue, mucosal drug delivery systems used for the adhesion of materials. Was made with the AGS as a substrate for nitric sigh membrane, placed in periodontal pockets treatment of periodontitis, achieved satisfactory results, and avoid long-term systemic adverse drug reactions.
2 material for wound healing
Wound repair materials to help promote wound healing is a medical biomaterials, tissue compatibility of these materials, plant or cover the wound and the body's adverse reaction does not occur, and can treat or replace body tissue in the defect and promote their healing. AGS is a kind of natural plant materials wound healing, with its production of gel diaphragm or sponge material can be used to protect the wound and treatment of burn and scald. AGS trauma care can be made with glycerin gel, dry skin membrane to become non-toxic soft gel or membrane containing drugs.Animal experiments show that it has to prevent bacterial infection of wounds and treatment of the role of film and easy to use water to wash away. Application AGS skin healing time of skin grafts, healing quality, and patient comfort are better than pigskin films. With the AGS as part of the inferior turbinate resection in patients with dressing material, dressing better than paraffin wax, remove the bandage can be particularly more pronounced reduction in bleeding. Sodium alginate with calcium (Ca2 +-GS) fibers can be successful in the treatment of toxic epidermal necrosis.
3 Treatment of reflux esophagitis
AGS treat oral postprandial gastroesophageal reflux (GER). Some children with AGS treatment of reflux esophagitis, GER can occur less often, shorter duration, esophageal pH, recovery speed, and can significantly reduce the incidence of vomiting. AGS as the main ingredient in chewing cover stomach plain film, is a domestic gastroesophageal acid reflux inhibitors, after swallowing after chewing, and saliva, gastric acid, to produce a floating viscous gel to form a full block back to physical barrier to protect the inflamed mucous membranes, promote healing. AGS in an oral treatment of reflux esophagitis controlled study, AGS is more effective than cisapride (cisapride).
4 to restore blood volume
701 made with the AGS injection, injection of Sodium alginate, sodium alginate oligosaccharides injection, said foreign Alginon, Glyco-Algin and so on. With increased blood volume, maintain blood pressure, can maintain a stable circulation before and after surgery for hemorrhagic shock, burns and shock, and acute diarrhea, dehydration, high fever due to systemic treatment, as well as the group generated by excluding burns rubber toxoid role.
5 Other
Documents extracted from wheat bran dietary fiber mixture of crushed and AGS, by adding 8% AGS as a thickening agent, plus 0.2% glucose sweet mix, and the other with 2% AGS for adhesives made from water soluble dietary fiber granules (DFG), the animal experiments and clinical observation. Results show that, DFG can significantly reduce high blood cholesterol in rats blood cholesterol (TC), triglycerides and low-density lipoprotein cholesterol (LDL-C), and the increase of these three indicators have a preventive role in normal rats glucose did not change, a significant increase in bowel movements; DFG can significantly reduce high blood cholesterol in patients with TC and LDL-C, significantly reduced Ⅰ, Ⅱ diabetes, fasting blood glucose, treatment of habitual constipation with efficiency of 100%. That long-term intake of 5% AGS will not only reduce blood fat rats, but can reduce liver fat, decreased liver weight / body weight ratio (P> 0.05), suggesting that the high-fat rats, the lower liver The role of lipid lowering body fat than the more significant. The prevention of high cholesterol and fatty liver, and can decrease platelet aggregation, useful for the prevention of thrombotic diseases, its better than carrageenan.
Studies, also, AGS can significantly promote the mouse peritoneal macrophage phagocytosis, and enhance humoral immunity and promote lymphocyte transformation of rat red blood cell agglutination significant role in promoting tumor S1809 has a certain extent, able to confront the cyclophosphamide-induced leukopenia. Can inhibit the body's absorption of lead, cadmium, strontium and other harmful non-factor. AGS with calcium, iron ions form a gel precipitation, the characteristics of improving water quality, cleaning up the environment has some economic value.
6 AGS adverse reactions
AGS mice by intraperitoneal injection of LD50 of (1 013 ± 308) mg · kg-1. 5 volunteers AGS results show that a large number of oral daily 175mg · kg0-1. 7d clothes, and then followed by daily 200mg · kg-1 even for 16d, in addition to the stool dry weight, wet weight and water content are increased, the clinical symptoms, and hematology, serology, enzymology, urine, feces and other tests were no any adverse reactions.
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